GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2273 | 1 | rs10008757 | chr4:76903036 | NAAA | chr4:76831809-76862166:- | -0.21 | -5.34 | 1.13E-7 | Longevity |
| BRCA | cis | rs1109501 | 1 | rs10011835 | chr4:71340722 | AMTN | chr4:71384298-71398459:+ | 0.26 | 7.59 | 7.07E-14 | Alcoholism (heaviness of drinking) |
| BRCA | cis | rs1008375 | 1 | rs10012335 | chr4:17628630 | MED28 | chr4:17616273-17629791:+ | 0.14 | 3.63 | 0.000301 | Parasitemia in Tripanosoma cruzi seropositivity |
| BRCA | cis | rs11799420 | 1 | rs1001373 | chr1:171684506 | VAMP4 | chr1:171669298-171711214:- | 0.19 | 5.4 | 8.1E-8 | Hippocampal atrophy |
| BRCA | cis | rs7659604 | 1 | rs10016433 | chr4:122664771 | EXOSC9 | chr4:122722472-122738175:+ | 0.13 | 4.27 | 2.1E-5 | Type 2 diabetes |
| BRCA | cis | rs2242330 | 1 | rs10017445 | chr4:68423787 | STAP1 | chr4:68424446-68473053:+ | -0.17 | -6.16 | 1.02E-9 | Parkinson's disease |
| BRCA | cis | rs1061377 | 1 | rs10018049 | chr4:39117401 | KLHL5 | chr4:39046659-39123828:+ | -0.16 | -5.03 | 5.75E-7 | Uric acid levels |
| BRCA | cis | rs6532023 | 1 | rs10023907 | chr4:88772535 | SPP1 | chr4:88896802-88904562:+ | -0.18 | -5.76 | 1.07E-8 | Bone mineral density;Bone mineral density (paediatric, total body less head) |
| BRCA | cis | rs3805389 | 1 | rs10026676 | chr4:56478752 | SRD5A3 | chr4:56212409-56237866:+ | -0.17 | -4.33 | 1.65E-5 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs2070488 | 1 | rs1002675 | chr3:38445226 | XYLB | chr3:38388251-38456467:+ | 0.19 | 5.68 | 1.7E-8 | Electrocardiographic conduction measures |
| BRCA | cis | rs2070488 | 1 | rs1002676 | chr3:38444932 | LOC100128640 | chr3:38492524-38496311:- | -0.14 | -3.78 | 0.000165 | Electrocardiographic conduction measures |
| BRCA | cis | rs2070488 | 1 | rs1002676 | chr3:38444932 | XYLB | chr3:38388251-38456467:+ | -0.21 | -6.3 | 4.29E-10 | Electrocardiographic conduction measures |
| BRCA | cis | rs1061377 | 1 | rs10026775 | chr4:39116775 | KLHL5 | chr4:39046659-39123828:+ | -0.16 | -4.99 | 7.02E-7 | Uric acid levels |
| BRCA | cis | rs11723261 | 1 | rs10027325 | chr4:282608 | ZNF718 | chr4:53272-156488:+ | 0.29 | 6.77 | 2.08E-11 | Immune response to smallpox vaccine (IL-6) |
| BRCA | cis | rs7665090 | 1 | rs10027437 | chr4:103557251 | MANBA | chr4:103552644-103682151:- | 0.19 | 4.97 | 7.68E-7 | Primary biliary cirrhosis |